amplicons
Exemples
1q21-q22 amplicon
12q13-12q14 amplicon
- target genes: CDK4 (12q14)
15q25-26 amplicon
- target genes: IGF1R
References
Bignell GR, Santarius T, Pole JC, Butler AP, Perry J, Pleasance E, Greenman C, Menzies A, Taylor S, Edkins S, Campbell P, Quail M, Plumb B, Matthews L, McLay K, Edwards PA, Rogers J, Wooster R, Futreal PA, Stratton MR. Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution. Genome Res. 2007 Sep;17(9):1296-303. PMID: 17675364