Several neurodegeneratives diseases are caused by aberrant beta-strand linkage of conformationally unstable proteins.
The common molecular features of these diseases is the formation of aberrant intermolecular beta-linkages, in which single peptides strands become aligned to form highly stable beta-sheets.
these beta-linked structures then accumulate to cause cell death and hence disease.
Types
| neuroserpin | Collins bdoy | familial encephalopathy with neuroserpin inclusion bodies |
| alpha-synuclein | Lewy body | familial parkinson disease |
| Prion protein | vGJD amyloid | Creutzfeldt-Jacob disease (CJD) |
| beta-amyloid peptide | beta-amyloid plaque | Alzheimer disease |
| Tau protein | Pick body | frontotemporal dementias (Pick disease) |
| huntingtin | Huntingtin inclusion | Huntington disease |
See also
conformational diseases
neurodegenerative diseases