Thyroid transcription factor-1 (TTF-1) is a 38-kd homeodomain containing DNA-binding protein originally identified in follicular cells of the thyroid and subsequently in pneumocytes.
Expression in normal cells
follicular cells of the thyroid
Expression in tumors
pulmonary small cell carcinomas (82.7%)
extrapulmonary small cell carcinomas (42.0%)
References
Lau SK, Luthringer DJ, Eisen RN. Thyroid transcription factor-1: a review. Appl Immunohistochem Mol Morphol. 2002 Jun;10(2):97-102. PMID: 12051643