Transcriptional regulation by nuclear hormone receptors is thought to involve interactions with putative cofactors that may potentiate receptor function.
Human thyroid hormone receptor (TR)-alpha (190120) purified from HeLa cells grown in the presence of thyroid hormone (T3) is associated with a group of distinct nuclear proteins termed thyroid hormone receptor-associated proteins (TRAPs).
The ’liganded’ TR/TRAP complex markedly activated transcription from a promoter template containing T3-response elements.
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