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Home > D. Systemic pathology > Hematologic disorders > T-cell acute lymphoblastic leukemia

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T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LL) and are often thought to represent a spectrum of a single disease. The malignant cells in T-ALL and T-LL are morphologically indistinguishable, and they share the expression of common cell surface antigens and cytogenetic characteristics. However, despite these similarities, differences in the clinical behavior of T-ALL and T-LL are observed.

Cytogenetics

- t(8;14)

References

- Screpanti I, Bellavia D, Campese AF, Frati L, Gulino A. Notch, a unifying target in T-cell acute lymphoblastic leukemia? Trends Mol Med. 2003 Jan;9(1):30-5. PMID: 12524208

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