Human pathology

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Sub-Saharan Africa

Facts

- More than a third of Yemen Hadramawt were of clear sub-Saharan origin. (12629598)
- Other Arab populations carried approximately 10% lineages of sub-Saharan origin, whereas non-Arab Near Eastern populations, by contrast, carried few or no such lineages, suggesting that gene flow has been preferentially into Arab populations. (12629598)
- Most of this gene flow probably occurred within the past approximately 2,500 years. (12629598)
- However, there is little evidence for male-mediated gene flow from sub-Saharan Africa in Y-chromosome haplotypes in Arab populations, including the Hadramawt. (12629598)
- Results are consistent with substantial migration from eastern Africa into Arabia, at least in part as a result of the Arab slave trade, and mainly female assimilation into the Arabian population as a result of miscegenation and manumission. (12629598)

- A back migration from Asia

  • Three main clusters of populations can be identified: northern, eastern, and sub-Saharan Africans. (11910562)
  • Among sub-Saharan Africans, the Khoisan, the Pygmies, and the northern Cameroonians are clearly distinct from a tight cluster formed by the Niger-Congo-speaking populations from western, central western, and southern Africa. (11910562)
  • Phylogeographic analyses suggest that a large component of the present Khoisan gene pool is eastern African in origin and that Asia was the source of a back migration to sub-Saharan Africa. Haplogroup IX Y chromosomes appear to have been involved in such a migration, the traces of which can now be observed mostly in northern Cameroon. (11910562)

References

- Richards M, Rengo C, Cruciani F, Gratrix F, Wilson JF, Scozzari R, Macaulay V, Torroni A. Extensive female-mediated gene flow from sub-Saharan Africa into near eastern Arab populations. Am J Hum Genet. 2003 Apr;72(4):1058-64. PMID: 12629598

- Cruciani F, Santolamazza P, Shen P, Macaulay V, Moral P, Olckers A, Modiano D, Holmes S, Destro-Bisol G, Coia V, Wallace DC, Oefner PJ, Torroni A, Cavalli-Sforza LL, Scozzari R, Underhill PA. A back migration from Asia to sub-Saharan Africa is supported by high-resolution analysis of human Y-chromosome haplotypes. Am J Hum Genet. 2002 May;70(5):1197-214. PMID: 11910562