SUFU
MIM.607035 10q24-q25
SUFU encodes a component of the sonic hedgehog/patched signaling pathway (SHH/PTCH signaling pathway).
Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes: HPE3) (MIM.142945), BCNS (MIM.109400) and GCPS (MIM.175700).
Pathology
- medulloblastoma