SLC1s
Definition: SLC1s are glutamate transporters. Glutamate transporters are membrane-bound proteins localized in glial cells and/or presynaptic glutamatergic nerve endings. They are essential for the removal and termination of action of the excitatory neurotransmitter glutamate from the synapse.
Several subtypes of glutamate transporters have been defined by differences in sequence, pharmacology, tissue distribution, and channel-like properties, including:
SLC1A2 (EAAT2)
SLC1A3 (EAAT1 or GLAST; MIM.600111)
SLC1A1 (EAAC1 or EAAT3; MIM.133550)
SLC1A6 (EAAT4; MIM.600637).
SLC1A2 (EAAT2) is selectively localized to astroglia; SLC1A1 and SLC1A6 are selectively localized in neurons; and SLC1A3 is found in both neurons and astroglia.