SETTLE
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Spindle epithelial tumor with thymus-like elements is a rare thyroid lesion of children and young adults thought to be derived from branchial pouch remnants or foci of ectopic thymus. The lesion is poorly understood, and although it was originally believed to follow an indolent clinical course, its potential for late metastasis is becoming generally acknowledged.
Evolution
possible local recurrence
very rare early micrometastasis
very rare metastatic dissemination occurring years after surgical resection of the primary lesion (16222481)
References
Erickson ML, Tapia B, Moreno ER, McKee MA, Kowalski DP, Reyes-Mugica M. Early metastasizing spindle epithelial tumor with thymus-like differentiation (SETTLE) of the thyroid. Pediatr Dev Pathol. 2005 Sep-Oct;8(5):599-606. PMID: 16222481