REL
2p13-p12 MIM.164910
RELs
cREL encodes a component of the nuclear factor B (NF-B) heterodimer.
Pathology
amplification of 2p13 in DLBCL (14%)
- increased cREL abundance might be associated with increased NF-B activity (?)
- BCL11A proto-oncogene has also been found to be simultaneously amplified with cREL in tumors with gains of chromosome 2p13
References
Foo SY, Nolan GP. NF-kappaB to the rescue: RELs, apoptosis and cellular transformation. Trends Genet. 1999 Jun;15(6):229-35. PMID: 10354583