Human pathology

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REL

2p13-p12 MIM.164910

RELs

cREL encodes a component of the nuclear factor B (NF-B) heterodimer.

Pathology

- amplification of 2p13 in DLBCL (14%)

  • increased cREL abundance might be associated with increased NF-B activity (?)
  • BCL11A proto-oncogene has also been found to be simultaneously amplified with cREL in tumors with gains of chromosome 2p13

References

- Foo SY, Nolan GP. NF-kappaB to the rescue: RELs, apoptosis and cellular transformation. Trends Genet. 1999 Jun;15(6):229-35. PMID: 10354583