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PKCs

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Activation of PKC through G protein coupled receptor (From biocarta)
protein kinases C, PKC
Member of a family of serine/threonine kinases.

Definition: PKCs are members of the protein kinase C (PKC) family, a superfamily of serine/threonine kinases. They function in many extracellular receptor-mediated signal transduction pathways.

Protein kinase C (PKC) comprises a family of serine/threonine kinases that are involved in the transduction of signals for cell proliferation, differentiation, apoptosis and angiogenesis.

Disruption of PKC regulation is implicated in tumorigenesis and drug resistance.

PKC function is complex in this context owing to the differing roles of individual isozymes within the cell and across tumour types. PKC isozymes, effectors of diacylglycerol (DAG) and the main targets of phorbol-ester tumour promoters, have important roles in cell-cycle regulation, cellular survival, malignant transformation and apoptosis.

Members

PRKCA PRKCB PRKCG PRKCM

Pathology

- missense mutations in the regulatory domain of PKC gamma in dominant nonepisodic cerebellar ataxia

References

- Griner EM, Kazanietz MG. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer. 2007 Apr;7(4):281-94. PMID: 17384583

- Mackay HJ, Twelves CJ. Targeting the protein kinase C family: are we there yet? Nat Rev Cancer. 2007 Jul;7(7):554-62. PMID: 17585335

- Boneh A. A model for PKC involvement in the pathogenesis of inborn errors of metabolism. Trends Mol Med. 2002 Nov;8(11):524-31. PMID: 12421686