Pathology
PICALM/AF10 fusion gene by t(10;11)(p13;q14) in acute leukemia.
This rearrangement is associated with a poor prognosis.
References
Bohlander, S. K.; Muschinsky, V.; Schrader, K.; Siebert, R.; Schlegelberger, B.; Harder, L.; Schemmel, V.; Fonatsch, C.; Ludwig, W.-D.; Hiddemann, W.; Dreyling, M. H. : Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients. Leukemia 14: 93-99, 2000. PubMed ID : 10637482
Carlson, K. M.; Vignon, C.; Bohlander, S.; Martinez-Climent, J. A.; Le Beau, M. M.; Rowley, J. D. : Identification and molecular characterization of CALM/AF10 fusion products in T cell acute lymphoblastic leukemia and acute myeloid leukemia. Leukemia 14: 100-104, 2000. PubMed ID : 10637483
Dreyling, M. H.; Martinez-Climent, J. A.; Zheng, M.; Mao, J.; Rowley, J. D.; Bohlander, S. K. : The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, a new member of the AP-3 clathrin assembly protein family. Proc. Nat. Acad. Sci. 93: 4804-4809, 1996. PubMed ID : 8643484
Dreyling, M. H.; Schrader, K.; Fonatsch, C.; Schlegelberger, B.; Haase, D.; Schoch, C.; Ludwig, W.-D.; Loffler, H.; Buchner, T.; Wormann, B.; Hiddemann, W.; Bohlander, S. K. : MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis. Blood 91: 4662-4667, 1998. PubMed ID : 9616163