therapy-related acute lymphoblastic leukemia
A highly increased risk of myelodysplasia (MDS) and acute myeloid leukaemia (AML) is well established in patients previously treated for other malignancies with alkylating agents or topoisomerase II inhibitors. Single cases of acute lymphoblastic leukaemia (ALL), often presenting balanced translocations involving chromosome band 11q23, have been observed.
Cytogenetics
11q23 rearrangements
- t(4;11)(q21;q23) (11552977)
Molecular biology
MLL fusion genes
References
Andersen MK, Christiansen DH, Jensen BA, Ernst P, Hauge G, Pedersen-Bjergaard J. Therapy-related acute lymphoblastic leukaemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new cases and review of the literature since 1992. Br J Haematol. 2001 Sep;114(3):539-43. PMID: 11552977
Thandla S, Alashari M, Green DM, Aplan PD.Therapy-related T cell lymphoblastic lymphoma with t(11;19)(q23;p13) and MLL gene rearrangement.Leukemia. 1999 Dec;13(12):2116-8. PMID: 10602439