NFKB2
MIM.164012
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NFKB1 (MIM.164011) or NFKB2 (MIM.164012) is bound to REL (MIM.164910), RELA (MIM.164014), or RELB (MIM.604758) to form the NFKB complex.
The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB.
The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA) (MIM.164008) or NFKBIB (MIM.604495), which inactivate NFKB by trapping it in the cytoplasm.
Phosphorylation of serine residues on the I-kappa-B proteins by kinases IKBKA (MIM.600664) or IKBKB (MIM.603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex.
Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
See also
| NFKBs | NFKB1 | NFKB2 | NFKB3 |
| RELs | REL | RELA | RELB |