Human pathology

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MLANA

MIM.605513 Ch.9

MART-1, melan-A, melanoma antigen recognized by T cells 1
Melanosome-associated protein.

Immunochemistry

A103 is a melanocyte-associated monoclonal antibody that recognizes the Melan-A/MART-1 antigen in melanomas.

Expression in tumors

- melanoma
- sex cord stromal tumors of the ovary (SCSTs) (12966351)
- adrenal cortical tumors (12808065)

  • adrenal cortical carcinoma

References

- Yan S, Brennick JB. False-positive Rate of the Immunoperoxidase Stains for MART1/MelanA in Lymph Nodes. Am J Surg Pathol. 2004 May;28(5):596-600. PMID: 15105646

- Busam KJ, Iversen K, Coplan KA, Old LJ, Stockert E, Chen YT, McGregor D, Jungbluth A. Immunoreactivity for A103, an antibody to melan-A (Mart-1), in adrenocortical and other steroid tumors. Am J Surg Pathol. 1998 Jan;22(1):57-63. PMID: 9422316