MIR34
miR-34s
Non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network.
Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53.
miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death.
References
He L, He X, Lowe SW, Hannon GJ. microRNAs join the p53 network?another piece in the tumour-suppression puzzle. Nat Rev Cancer. 2007 Nov;7(11):819-22. PMID: 17914404