MEN1
MIM.131100 11q13
MEN1 is a likely tumor suppressor gene that encodes a novel protein, menin. Menin is a 610 amino-acid residue protein with as yet unknown function(s).
Function
menin associates with nonmuscle myosin II-A heavy chain (14508515)
menin through binding to NMHC II-A could participate in cell division and in other processes that involve NMHC II-A (14508515)
menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation (11526476)
menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription (9989505)
Pathology
germline mutation in multiple endocrine neoplasia type 1 (MEN1)
References
Marx SJ. Molecular genetics of multiple endocrine neoplasia types 1 and 2. Nat Rev Cancer. 2005 May;5(5):367-75. PMID: 15864278
Agarwal SK, Lee Burns A, Sukhodolets KE, Kennedy PA, Obungu VH, Hickman AB, Mullendore ME, Whitten I, Skarulis MC, Simonds WF, Mateo C, Crabtree JS, Scacheri PC, Ji Y, Novotny EA, Garrett-Beal L, Ward JM, Libutti SK, Richard Alexander H, Cerrato A, Parisi MJ, Santa Anna-A S, Oliver B, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ. Molecular pathology of the MEN1 gene. Ann N Y Acad Sci. 2004 Apr;1014:189-98. PMID: 15153434
Schussheim DH, Skarulis MC, Agarwal SK, Simonds WF, Burns AL, Spiegel AM, Marx SJ. Multiple endocrine neoplasia type 1: new clinical and basic findings. Trends Endocrinol Metab. 2001 May-Jun;12(4):173-8. PMID: 11295574