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MBL2

The MBL2 gene encodes a mannose-binding lectin (MBL), or protein (MBP), that is secreted by the liver as part of the acute-phase response and is involved in innate immune defense.

The ligands for MBL are expressed by a wide variety of microorganisms, and binding of the protein leads to opsonization as well as activation of the complement system.

Pathology

- germline mutations of MBL2 in mannose-binding protein deficiency (MIM.154545)

See also

- MBLs

  • MBL1