MAP2Ks
Some cell surface receptors respond to extracellular stimuli via a sequential protein kinase cascade. The kinase signaling cascades involve multiple protein kinases, including the mitogen-activated protein kinase kinases (MAP2Ks, also called MAPKKs or PRKMKs) and the mitogen-activated protein kinases (MAPKs, or PRKMs). Specific MAP2Ks have been shown to phosphorylate specific MAPKs in a given pathway.
References
Sato Y, Harada K, Kizawa K, Sanzen T, Furubo S, Yasoshima M, Ozaki S, Ishibashi M, Nakanuma Y. Activation of the MEK5/ERK5 cascade is responsible for biliary dysgenesis in a rat model of Caroli’s disease. Am J Pathol. 2005 Jan;166(1):49-60. PMID: 15631999