LIMs
LIM proteins contain a highly conserved double zinc finger motif called the LIM domain. LIM genes constitute a large gene family whose gene products carry the LIM domain, a unique cysteine-rich zinc-binding domain.
At least 40 members of this family have been identified in vertebrates and invertebrates, and are distributed into 4 groups according to the number of LIM domains and to the presence of domains such as homeodomains and kinase domains.
LIM-homeodomain proteins are characterized by the presence of 2 tandem cysteine/histidine-rich, zinc-binding LIM domains.
Members
| LHXs | LHX1 | LHX2 | LHX3 | LHX4 | LHX5 | LHX6 | LHX7 | LHX8 | LHX9 |
| LMXs | LMX1A | LMX1B | |||||||
| LMOs | LMO1 | LMO2 | LMO3 | LMO4 | LMO5 | LMO6 | LMO7 | ||
| FHLs | FHL1 | FHL2 | FHL3 |
Pathology
LMX1B germline mutations in nail-patella syndrome
See also
transcription factors
References
Hobert O, Westphal H. Functions of LIM-homeobox genes. Trends Genet. 2000 Feb;16(2):75-83. PMID: 10652534