Human pathology

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LCHAD deficiency

long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD)/mitochondrial trifunctional protein (MTP) deficiency

Synopsis

- hypoketotic hypoglycemia
- rhabdomyolysis
- cardiomyopathy
- retinopathy
- peripheral neuropathy
- in pregnant mother

  • acute fatty liver of pregnancy
  • hemolysis
  • elevated liver enzymes
  • low platelets

References

- Oey NA, DEN Boer ME, Wijburg FA, Vekemans M, Auge J, Steiner C, Wanders RJ, Waterham HR, Ruiter JP, Attie-Bitach T. Long-Chain Fatty Acid Oxidation during Early Human Development. Pediatr Res. 2005 Apr 21; PMID: 15845636