The JNK pathway is activated by many stimuli including inflammatory factors such as IL-1 and TNF and activates c-jun transcriptional activation.
JUN (c-Jun), as part of AP-1, activates immediate early genes that are rapidly activated in response to growth factors or inflammatory signals.
Links
JNK signaling pathway at Linnea
References
Kaneto H, Matsuoka TA, Katakami N, Kawamori D, Miyatsuka T, Yoshiuchi K, Yasuda T, Sakamoto K, Yamasaki Y, Matsuhisa M. Oxidative stress and the JNK pathway are involved in the development of type 1 and type 2 diabetes. Curr Mol Med. 2007 Nov;7(7):674-86. PMID: 18045145
Bogoyevitch MA. Therapeutic promise of JNK ATP-noncompetitive inhibitors. Trends Mol Med. 2005 May;11(5):232-9. PMID: 15882611
Pearce AK, Humphrey TC. Integrating stress-response and cell-cycle checkpoint pathways. Trends Cell Biol. 2001 Oct ;11(10):426-33. PMID : 11567876