GRP78 (HSPA5), also referred to as ’immunoglobulin heavy chain-binding protein’ (BiP), is a member of the heat-shock protein-70 (HSP70) family.
HSPA5 is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER).
Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.
Pathology
GRP78 expression correlates with histologic differentiation and favorable prognosis in neuroblastic tumors. (15514946)
References
Expression patterns of Trk-A, Trk-B, GRP78, and p75NRT in olfactory neuroblastoma. Weinreb I, Goldstein D, Irish J, Perez-Ordonez B. Hum Pathol. 2009 Apr 20. PMID: 19386345
GRP78 expression correlates with histologic differentiation and favorable prognosis in neuroblastic tumors. Hsu WM, Hsieh FJ, Jeng YM, Kuo ML, Tsao PN, Lee H, Lin MT, Lai HS, Chen CN, Lai DM, Chen WJ. Int J Cancer. 2005 Mar 1;113(6):920-7. PMID: 15514946