HPV-18/MYC amplicon
The unscheduled replication origin activation at inserted HPV-18 viral DNA sequences triggers DNA amplification and the subsequent overexpression of the MYC oncogene.
References
Conti C, Herrick J, Bensimon A. Unscheduled DNA replication origin activation at inserted HPV 18 sequences in a HPV-18/MYC amplicon. Genes Chromosomes Cancer. 2007 Apr 19;46(8):724-734 PMID: 17444495