HER2
17q
HER-2/neu, HER-2, neu
The HER2 gene, located on 17q, encodes a 185-kD transmembrane tyrosine kinase receptor. Amplification of this gene with overexpression of the gene product occurs in about 30% of cases of breast cancer and is considered to be a poor prognostic indicator for this tumor.
Pathology
HER-2/neu gene amplification in breast cancer