Good syndrome
Immunodeficiency with thymoma
Immunodeficiency with thymoma (Good syndrome) (GS) is a rare, adult-onset condition that is characterized by thymoma, hypogammaglobulinemia, and low numbers of peripheral B cells.
Synopsis
+/- CD4+ T lymphopenia
+/- inverted CD4:CD8+ T-cell ratio
infections
- recurrent sinopulmonary infections
- encapsulated bacteria (Haemophilus influenzae)
- severe cytomegalovirus infections (CMV infections) disease
- Pneumocystis carinii pneumonia
- bacteremia
-
candidiases
- oral candidiasis or esophageal candidiasis
- persistent mucocutaneous candidiasis
- candidemia
- chronic diarrhea
- urinary tract infections
- tuberculosis
- Kaposi sarcoma
- disseminated varicella
- infection with Clostridium perfringens
- Mycoplasma arthritis
References
Tarr PE, Sneller MC, Mechanic LJ, Economides A, Eger CM, Strober W, Cunningham-Rundles C, Lucey DR. Infections in patients with immunodeficiency with thymoma (Good syndrome). Report of 5 cases and review of the literature. Medicine (Baltimore). 2001 Mar;80(2):123-33. PMID: 11307588