GLI1
MIM.165220 12q13.2-q13.3
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Definition: GLI is a Zinc Finger transcription factor that is the transcription factor of the Hedgehog signaling pathway.
Gli code hypothesis (17845852)
The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape.
Hh and other inputs are then just ways to modify the Gli code. Recent data confirm this idea and suggest that the Gli code regulates stemness and also tumor progression and metastatic growth, opening exciting possibilities for both regenerative medicine and novel anticancer therapies.
Pathology
GLI amplification in tumors
References
Ruiz i Altaba A, Mas C, Stecca B. The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends Cell Biol. 2007 Sep;17(9):438-47. PMID: 17845852
Aza-Blanc P, Kornberg TB. Ci: a complex transducer of the hedgehog signal. Trends Genet. 1999 Nov;15(11):458-62. PMID: 10529809
Bigner, S. H.; Mark, J.; Burger, P. C.; Mahaley, M. S., Jr.; Bullard, D. E.; Muhlbaier, L. H.; Bigner, D. D. : Specific chromosomal abnormalities in malignant human gliomas. Cancer Res. 88: 405-411, 1988.
Chung, R. Y.; Seizinger, B. R. : Molecular genetics of neurological tumours. J. Med. Genet. 29: 361-367, 1992. PubMed ID : 1320124
Kinzler, K. W.; Bigner, S. H.; Bigner, D. D.; Trent, J. M.; Law, M. L.; O’Brien, S. J.; Wong, A. J.; Vogelstein, B. : Identification of an amplified, highly expressed gene in a human glioma. Science 236: 70-73, 1987. PubMed ID : 3563490
Nilsson, M.; Unden, A. B.; Krause, D.; Malmqwist, U.; Raza, K.; Zaphiropoulos, P. G.; Toftgard, R. : Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Proc. Nat. Acad. Sci. 97: 3438-3443, 2000. PubMed ID : 10725363