FLI1
FLI-1 antibody is a useful marker for Ewing?s sarcoma/ Primitive neuroectodermal tumor (EWS/PNET) and vascular tumors. However, it is also expressed in subsets of lymphoblastic lymphoma, Merkel cell carcinoma (MCC) and desmoplastic small round cell tumor (DSRCT).
Immunochemistry
46/62 EWS/PNET
2/3 olfactory neuroblastoma
7/102 small cell carcinoma of the lung
10/34 MCC
1/14 rhabdomyosarcoma
19/132 non-Hodgkin?s lymphomas (NHL)
2/3 DSRCT
27/508 squamous cell carcinomas
19/837 adenocarcinomas
10/400 urothelial bladder cancer
1/40 basal cell carcinoma
3/29 liposarcoma
1/40 glioblastoma multiforme
9/29 medullar carcinoma of the breast
References
Mhawech-Fauceglia P, Herrmann F, Bshara W, Odunsi K, Terracciano L, Sauter G, Cheney RT, Groth J, Penetrante R. FLI-1 Expression in 4323 malignant and benign tumours: a multiple tumour tissue microarray analysis using polyclonal antibody. J Clin Pathol. 2006 Aug 17; PMID: 16917000