Human pathology

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FIP1L1

MIM.607686 4q12

Pathology

- PDGFRA/FIP1L1 gene fusion in

  • chronic eosinophilic leukemia (idiopathic hypereosinophilic syndrome) (MIM.607685)
  • eosinophilia-associated acute myeloid leukemia (17377585)
  • lymphoblastic T-cell lymphoma (17377585)

References

- Metzgeroth G, Walz C, Score J, Siebert R, Schnittger S, Haferlach C, Popp H, Haferlach T, Erben P, Mix J, Müller MC, Beneke H, Müller L, Del Valle F, Aulitzky WE, Wittkowsky G, Schmitz N, Schulte C, Müller-Hermelink K, Hodges E, Whittaker SJ, Diecker F, Döhner H, Schuld P, Hehlmann R, Hochhaus A, Cross NC, Reiter A.Recurrent finding of the FIP1L1-PDGFRA fusion gene in eosinophilia-associated acute myeloid leukemia and lymphoblastic T-cell lymphoma.Leukemia. 2007 Jun;21(6):1183-8. PMID: 17377585