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FAM123B

WTX, family with sequence similarity 123, member 123

WTX (or FAM123B) is a new X chromosome tumor suppressor gene. WTX is commonly inactivated in Wilms? tumor.

Pathology

- WTX inactivation in sporadic Wilms tumor (MIM.194070) with tumoral deletions at chromosome Xq11.1

- WTX inactivation by t(X;18)(q11;p11) with deletion of the WTX locus at Xq11. (17620295)

References

- Han M, Rivera MN, Batten JM, Haber DA, Cin PD, Iafrate AJ. Wilms? tumor with an apparently balanced translocation t(X;18) resulting in deletion of the WTX gene. Genes Chromosomes Cancer. 2007 Oct;46(10):909-13. PMID: 17620295

- Major MB, Camp ND, Berndt JD, Yi X, Goldenberg SJ, Hubbert C, Biechele TL, Gingras AC, Zheng N, Maccoss MJ, Angers S, Moon RT. Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science. 2007 May 18;316(5827):1043-6. PMID: 17510365

- Nusse R. Cancer. Converging on beta-catenin in Wilms tumor. Science. 2007 May 18;316(5827):988-9. PMID: 17510350

- Huff V. Wilms tumor genetics: a new, UnX-pected twist to the story. Cancer Cell. 2007 Feb;11(2):105-7. PMID: 17292822

- Bagchi S. New tumour suppressor linked to Wilms? tumour. Lancet Oncol. 2007 Feb;8(2):102. No abstract available. PMID: 17290504

- Rivera, M. N.; Kim, W. J.; Wells, J.; Driscoll, D. R.; Brannigan, B. W.; Han, M.; Kim, J. C.; Feinberg, A. P.; Gerald, W. L.; Vargas, S. O.; Chin, L.; Iafrate, A. J.; Bell, D. W.; Haber, D. A. : An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. Science 315: 642-645, 2007. PubMed ID : 17204608