Function
subunit A functions as an intracellular enzyme in platelets and monocytes/macrophages
cytoskeletal remodelling associated with the activation stages of platelets
mainly localised in the cytoplasm, in association with cytoskeletal filaments, but at a relatively early stage of macrophage differentiation it also appears transiently in the nucleus
Expression profile
platelets
megakaryocytes
monocytes/macrophages
papillary dermal dendrocytes
Pathology entities:
congenital factor XIII deficiency
Immunochemistry in tumoral pathology
dermatofibroma (benign fibrous histiocytoma)
angiofibroma (fibrous papule)
juvenile xanthogranuloma (12717244)
aneurysmal fibrous histiocytoma (12484439)
solitary fibrous tumor (12357210)