EWSR1/WT1
Pathology
fusion gene in tumors
- desmoplastic small round cell tumor (DSRCT)
- EWSR1/WT1-associated spindle cell tumor (17325488)
References
Alaggio R, Rosolen A, Sartori F, Leszl A, d’Amore ES, Bisogno G, Carli M, Cecchetto G, Coffin CM, Ninfo V. Spindle cell tumor with EWS-WT1 transcript and a favorable clinical course: a variant of DSCT, a variant of leiomyosarcoma, or a new entity? Report of 2 pediatric cases. Am J Surg Pathol. 2007 Mar;31(3):454-9. PMID: 17325488
Werner H, Idelman G, Rubinstein M, Pattee P, Nagalla SR, Roberts CT Jr. A novel EWS-WT1 gene fusion product in desmoplastic small round cell tumor is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene. Cancer Lett. 2007 Mar 8;247(1):84-90. PMID: 16730884
Kim J, Lee K, Pelletier J. The DNA binding domains of the WT1 tumor suppressor gene product and chimeric EWS/WT1 oncoprotein are functionally distinct. Oncogene. 1998 Feb 26;16(8):1021-30. PMID: 9519876