Pathology
EWS/FLI1 fusion gene in Ewing sarcoma/peripheral primitive neuroectodermal tumors
EWS/FLI1 fusion gene in one case of solid pseudopapillary tumor of the pancreas (11000339)
Biology
Ewing tumor fusion proteins block the differentiation of pluripotent marrow stromal cells (12839926)
EWS/FLI-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/peripheral primitive neuroectodermal tumors (14973077)
References
Uren A, Toretsky JA. Ewing’s sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent. Future Oncol. 2005 Aug;1(4):521-8. PMID: 16556028
Rorie CJ, Thomas VD, Chen P, Pierce HH, O’Bryan JP, Weissman BE. The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/peripheral primitive neuroectodermal tumors. Cancer Res. 2004 Feb 15;64(4):1266-77. PMID: 14973077
Hahm KB, Cho K, Lee C, Im YH, Chang J, Choi SG, Sorensen PH, Thiele CJ, Kim SJ. Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein. Nat Genet. 1999 Oct;23(2):222-7. PMID: 10508522
Lessnick SL, Braun BS, Denny CT, May WA. Multiple domains mediate transformation by the Ewing’s sarcoma EWS/FLI-1 fusion gene. Oncogene. 1995 Feb 2;10(3):423-31. PMID: 7845667
Ohno T, Rao VN, Reddy ES. EWS/Fli-1 chimeric protein is a transcriptional activator. Cancer Res. 1993 Dec 15;53(24):5859-63. PMID: 7503813