ETV6/RUNX1-associated leukemia
Near-tetraploidy (82-94 chromosomes) makes up fewer than 1% of childhood acute lymphoblastic leukemia (ALL) cases and has been reportedly associated with a possibly poorer prognosis compared with other ploidy groups.
CYtogenetics
Near-tetraploidy is a specific feature of ETV6/RUNX1+ BCP ALL (16552772).
References
Amare Kadam PS, Raje GC, Pais AP, Banavali S. Coexistence of ETV6/RUNX1 and MLL aberrations in B-cell precursor acute lymphoblastic leukemia discloses a small subclass of BCP-ALL. Cancer Genet Cytogenet. 2008 Apr 1;182(1):27-32. PMID: 18328947
Attarbaschi A, Mann G, Konig M, Steiner M, Dworzak MN, Gadner H, Haas OA; Austrian Berlin-Frankfurt-Munster Cooperative Study Group. Near-tetraploidy in childhood B-cell precursor acute lymphoblastic leukemia is a highly specific feature of ETV6/RUNX1-positive leukemic cases. Genes Chromosomes Cancer. 2006 Jun;45(6):608-11. PMID: 16552772