Pathology
ETV6-NTRK3 fusion gene by translocation t(12;15)(p13;q25)
- congenital fibrosarcoma (9462753)
- mesoblastic nephroma (9811336, 9823307)
- chronic myeloid leukemia
- secretory breast carcinoma (15101049)
Bioogy
chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation (11751416)
ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation (12173038)
References
Bourgeois JM, Knezevich SR, Mathers JA, Sorensen PH. Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors. Am J Surg Pathol. 2000 Jul;24(7):937-46. PMID: 10895816