The cullin gene family (CULs) includes at least 5 members in nematodes, 6 in humans, and 3 in S. cerevisiae. The partial C-terminal amino acid sequences of CUL4A and CUL4B share 88% identity.
Pathology
germline mutation in CUL4B in X-Linked Mental Retardation (17273978)
See also
CULS
- CUL1 (MIM.603134)
- CUL4A (MIM.603137)
References
Zou Y, Liu Q, Chen B, Zhang X, Guo C, Zhou H, Li J, Gao G, Guo Y, Yan C, Wei J, Shao C, Gong Y. Mutation in CUL4B, Which Encodes a Member of Cullin-RING Ubiquitin Ligase Complex, Causes X-Linked Mental Retardation. Am J Hum Genet. 2007 Mar;80(3):561-6. PMID: 17273978