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CPAM type 1

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CPAM type 1 CPAM type 1
CCAM type 1, CCAM type I, congenital cystic adenomatoid malformation type I, congenital pulmonary airway malformation type 1

CCAM type 1 (60-70%) (bronchial) (neonates and infants, resectable, good prognosis, possible carcinomatous change)

Synopsis

- 60-70%
- bronchial type
- neonates and infants
- resectable
- good prognosis
- possible carcinomatous change (bronchioloalveolar carcinoma)
- 1 or more large cysts measuring 2-10 cm in diameter
- larger cysts are often accompanied by smaller cysts
- cyst walls containing muscle, elastic, or fibrous tissue
- cysts frequently lined by pseudostratified columnar epithelial cells often interspersed with rows of mucous cells
- focal mucous cell hyperplasia (12 to 25% of type 1 CCAM)
- microscopic foci of bronchioloalveolar carcinoma (1 to 31% of type 1 CCAM) (12883247)

References

- MacSweeney F, Papagiannopoulos K, Goldstraw P, Sheppard MN, Corrin B, Nicholson AG. An assessment of the expanded classification of congenital cystic adenomatoid malformations and their relationship to malignant transformation. Am J Surg Pathol. 2003 Aug;27(8):1139-46. PMID: 12883247