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COL2s

Fibril-forming collagens

The collagens fall into 2 major classes: the fibril-forming collagens and the nonfibril-forming collagens.

A long central triple-helical domain, without gly-Xaa-Xaa interruptions, is the hallmark of the fibril-forming collagens. Are members of this class:

- collagens type I (COL1s)
- collagens type II (COL2s)
- collagens type III (COL3S)
- collagens type V (COL5s)
- collagens type XI (COL9s), which form highly organized fibrils in a quarter-staggered fashion

Pathology

- germline mutaions of COL2A1 in:

Keywords