CLIP
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class II-associated invariant chain peptide
Function
The class II-associated invariant chain peptide (CLIP) associates with newly synthesized class II molecules in the endoplasmic reticulum (ER), an interaction that has been shown to interfere with peptide binding to class II molecules.
The class II-associated invariant chain peptide (CLIP) region (residues 81- 104) of Ii is believed to mediate this inhibition by engaging the binding domain of class II like an antigenic peptide.
CLIP association with the class II groove acts to prevent inappropriate presentation of peptides imported into the ER for association with major histocompatibility complex class I molecules.