stimulation of changes in the actin cytoskeleton
establishment of cell polarity
regulation of intracellular trafficking
regulation of cell growth
regulation of the processing of the EGF receptor
GTPase signaling is essential for proper myelination of the peripheral nervous system, and Cdc42-mediated cell-shape changes in transfected Schwann cells.
Pathology
FGD4 is a GEF for the Rho GTPase cell-division cycle 42 (Cdc42).
- FGD4 causes peripheral nerve demyelination in patients with autosomal recessive Charcot-Marie-Tooth (CMT) neuropathy type 4H (CMT4H).
Signaling pathways
CDC42 signaling pathway (Linnea)
References
Cerione RA. Cdc42: new roads to travel. Trends Cell Biol. 2004 Mar;14(3):127-32. PMID: 15003621