CD57
CD57 is a glycoprotein with cell adhesion functions
Expression in normal cells
NK cells (NK cells with no TCR membrane expression or gene rearrangement)
neuroendocrine cells
T cell subset (CD2,3,5)
neuroectodermal tissue
brain
prostate
proximal tubules of kidney
Subset of NK cells
CD16+, CD57-: substantial NK activity
CD16-, CD57-: no NK activity
CD16-, CD57+: weak NK activity
CD16+, CD57+: variable NK activity
Expression in tumors
NK/T cell nasal lymphoma (poor prognosis)
neuroectodermal tumors
small cell lung cancer (some)
prostatic adenocarcinoma
nerve sheath origin lesions
metanephric adenoma
renal carcinoid tumors
some clear cell renal cell carcinomas
spindle cell thymomas
lymphomas (some)