CD4+/CD56+ hematodermic tumor
CD4(+)CD56(+) hematodermic neoplasms
CD4(+)CD56(+) hematodermic neoplasms (HNs) with initial presentation in the skin are characterized by highly aggressive behavior and poor prognosis. Recent studies indicate that malignant cells, which are devoid of common T-, B-, NK-, and myeloid lineage markers, may be of plasmacytoid dendritic cell (pDC) origin.
Immunochemistry
CD4+
CD56+
CD123+
fine membranous BDCA-2 staining of the dermal infiltrate
MxA protein +
References
Urosevic M, Conrad C, Kamarashev J, Asagoe K, Cozzio A, Burg G, Dummer R. CD4(+)CD56(+) hematodermic neoplasms bear a plasmacytoid dendritic cell phenotype. Hum Pathol. 2005 Sep;36(9):1020-4. PMID: 16153467