CD1 molecules are a family of major histocompatibility complex (MHC)-related glycoproteins that present lipid and glycolipid antigens to T cells.
CD1d-restricted T cells have a pathogenic role in atherosclerosis. It could be an association between the cellular machinery that loads CD1 molecules with glycolipids and several key proteins in lipid metabolism.
These proteins include the sphingolipid activator proteins (SAPs), microsomal triglyceride transfer protein (MTP) and apolipoprotein E (apoE). MTP and SAPs seem to be crucial for loading CD1d with lipids in the endoplasmic reticulum and endosomal compartments, respectively.
ApoE facilitates efficient uptake and delivery of exogenous lipid antigens to CD1d in endosomal compartments.
Members
| CD1a | CD1b | CD1c | CD1d | CD1e |
See also
CDs
References
Major AS, Joyce S, Van Kaer L. Lipid metabolism, atherogenesis and CD1-restricted antigen presentation. Trends Mol Med. 2006 Jun;12(6):270-8. PMID: 16651026