CD107a
MIM.153330
lysosome-associated membrane protein 1 (LAMP-1)
See: LAMP1
surface antigen transiently present on cell surface of CD8+ T cells after release of cytolytic granules
basophil activation antigen
expression correlates with aggressiveness of melanocytic neoplasms
critical to phagosomes acquiring microbicidal capabilities
ligand to E-selectin mediated cell adhesion
Use
defective CD107a surface expression discriminates between genetic subtypes of familial hemophagocytic lymphohistiocytosis
used to measure degranulation in CD8+ T cells by flow cytometry and NK cell activity / cytolytic capacity
Positive staining
primarily endosome-lysosome membranes, 1-2% on plasma membrane
degranulated platelets
activated neutrophils
T cells
endothelium