CCND1
MIM.168461 11q13
The proto-oncogene cyclin D1 has been implicated in the genesis of a large proportion of human tumors from diverse histological origins.
Function
activator of cdk4 and cdk6 in progression through the G1 phase of the cell cycle
Pathology
germline mutations in familial cylindromatosis
somatic mutations in
- sporadic spiradenocylindroma (11756779)
References
Strobel P, Zettl A, Ren Z, Starostik P, Riedmiller H, Storkel S, Muller-Hermelink HK, Marx A. Spiradenocylindroma of the kidney: clinical and genetic findings suggesting a role of somatic mutation of the CYLD1 gene in the oncogenesis of an unusual renal neoplasm. Am J Surg Pathol. 2002 Jan;26(1):119-24. PMID: 11756779
Chung DC. Cyclin D1 in human neuroendocrine tumorigenesis. Ann N Y Acad Sci. 2004 Apr;1014:209-17. PMID: 15153436
Ewen ME, Lamb J. The activities of cyclin D1 that drive tumorigenesis. Trends Mol Med. 2004 Apr;10(4):158-62. PMID: 15059606