BRCA1 and BRCA2 contribute to homologous recombination and DNA repair, to embryonic proliferation, to transcriptional regulation and, for BRCA1, to ubiquitination.
Pathology
germline mutationso of BRCA2 in
- high risks of breast and ovarian cancer
- Fanconi syncrome (Fanconi anemia - FA)
somatic mutations of BRCA2 in
- medulloblastoma
References
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