BMP7, a member of the transforming growth factor-beta superfamily, was shown to counteract transforming growth factor-beta-mediated fibrosis.
Bone morphogenetic proteins (BMPs) make up a family of extracellular signaling molecules that play a critical role in vertebrate development and both inhibit and stimulate growth in cancer cells.
BMP7 was recently identified in our genomewide copy number and expression survey as being activated through amplification in breast cancer cell lines.
Pathology
BMP7 copy number increase (16%) (16419056)
overexpression of the BMP7 protein (16419056)
- strongly elevated BMP7 protein expression by immunochemistry (71.4%) (16419056)
NB: There was no significant association between copy number increase and mRNA expression, even though the highest expression was seen in cell lines and tumors with increased BMP7 copy number.
Reviews
Patel SR, Dressler GR. BMP7 signaling in renal development and disease. Trends Mol Med. 2005 Nov;11(11):512-8. PMID: 16216558
References
Alarmo EL, Rauta J, Kauraniemi P, Karhu R, Kuukasjarvi T, Kallioniemi A. Bone morphogenetic protein 7 is widely overexpressed in primary breast cancer. Genes Chromosomes Cancer. 2006 Apr;45(4):411-9. PMID: 16419056