Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta superfamily of proteins (TGFBs). Dysregulation of BMP signaling has been suggested in the carcinogenesis of different organs.
Pathology
clear cell renal cell carcinoma
Clear Cell Renal Carcinoma tissue had significantly higher BMP-6 mRNA expression than healthy tissue. There is no significant correlation between BMP-6 mRNA and protein expression with disease presentation, disease progression and patients’ characteristics. Long-term follow-up of our patients is needed to determine the possible role of increased expression of BMP-6 in CCRC.
References
Immunolocalization and mRNA Expression of Bone Morphogenetic Protein-6 in Human Clear Cell Renal Carcinoma. Basic-Jukic N, Radic-Antolic M, Hudolin T, Coric M, Zadro R, Pasini J, Kastelan Z, Kes P. Kidney Blood Press Res. 2009 Dec 17;32(6):445-450. PMID: 20016212