Arias-Stella reaction
Definition: Highly excretive gland epithelium due to increased gonadotropin stimulation. An endometrial gland cell abnormality consisting of hyperchromatic nuclei, which may be present in normal or ectopic pregnancy.
Synopsis
vacuolated clear cytoplasm
intraglandular tufts
hobnail cells
oxyphilic cytoplasm
delicate filiform papillae
intranuclear pseudoinclusions
cribriform intraglandular growth
superficial glands
deep glands
confluent or extensive gland involvement
Differential diagnosis
cervical clear cell carcinoma
- lack of a mass suspicious for cancer
- absence of a desmoplastic response
- lack of an infiltrative pattern
- spectrum of cytologic atypia
- low nuclear-cytoplasmic ratio
- usual lack of mitotic activity
References
Nucci MR, Young RH. Arias-Stella Reaction of the Endocervix: A Report of 18 Cases With Emphasis on Its Varied Histology and Differential Diagnosis. Am J Surg Pathol. 2004 May;28(5):608-612. PMID: 15105648