See also
histiocytoses
ALK immunoreactivity
Clinical synopsis
pallor
massive hepatosplenomegaly
anemia
thrombocytopenia
Microscopical synopsis
Liver: infiltration of the sinusoids by large histiocytes with markedly folded nuclei, fine chromatin, small nucleoli, and voluminous lightly eosinophilic cytoplasm that sometimes was vacuolated or contained phagocytosed blood cells. (18660380)
Cutaneous infiltrates morphologically resembling juvenile xanthogranuloma.
Histiocytes immunoreactive for histiocytic markers (CD68, CD163, lysozyme), S100 protein, ALK (membranous and cytoplasmic pattern), and dendritic cell markers (fascin, factor XIIIa), but not CD1a and langerin. (18660380)
Molecular biology
One case out of 3 with TPM3-ALK fusion gene (18660380)
References
Chan JK, Lamant L, Algar E, Delsol G, Tsang WY, Lee KC, Tiedemann K, Chow CW. ALK+ histiocytosis: a novel type of systemic histiocytic proliferative disorder of early infancy. Blood. 2008 Oct 1;112(7):2965-8. PMID: 18660380